Why does Benadryl make us sleepy?

Benadryl medicine has a chemical named, diphenhydramine. It is an antihistamine that counter-affects histamine, a nitrogenous compound that is crucial for maintaining our body’s local immune system. The brain cells responsible for our wakefulness state, release histamine. Benadryl has antihistamines to reverse the effect of histamines. They encourage drowsiness and relieve allergy symptoms.

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